Effect of Short Time Morphine Addiction on the Kidney Tissue in Rat

Abstract

Opium is an important substance that abuses and has very pharmacological and pathological effects. Morphine is the main substance of opium. In the recent study, it has been tried to identify the short effects of morphine on the kidney pathology of Rats. The randomized double blind study was designed. Twenty rats were selected and divided in two groups and maintained under routine laboratory conditions and similar intervention. One group had been addicted orally by morphine powder and control were not addict. After three weeks, all rats were anesthetized and underwent autopsy. Their kidneys were removed en-block and sent to pathology laboratory and reviewed by one pathologist. The major considered variables were tubulo-interstitial and glomerular changes, glomerular amount and size on light microscope view. Glomerular, tubular and vascular changes, glomerular counts, glomerular size, and cortical thickness showed no significant differences between groups of study. Only Lymphocytic infiltration was higher frequency in addict group, significantly P = 0.007. It seems short course of morphine consumption is very little effect on kidney, only Lymphocytic infiltration observe in addicted renal tissue which, may be precursor of other changes in kidney. It is better long term studies are implemented in this course.