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Frequency: Quarterly
ISSN: 1553-6203 (Print)
ISSN: 1558-6340 (Online)
Research Article Open Access

Abnormal Glucose Regulation and Treatment Strategies for Insulin Resistance HIV-Infected Patients

Steven Grinspoon1
  • 1 Mass General Hospital and Harvard Medical School, United States

Abstract

HIV-infected patients receiving highly active antiretroviral therapy often demonstrate abnormalities in glucose regulation, in association with changes in fat distribution[1,2]. In the majority of cases, these abnormalities are best characterized by insulin resistance and impaired glucose tolerance, rather than overt diabetes mellitus and fasting hyperglycemia. Insulin resistance may result from direct effects of antiretroviral therapy, changes in fat distribution or abnormal regulation of fat metabolism and adipocytokines. Use of insulin sensitizing agents may be rationale to reduce cardiovascular risk and improve related metabolic and body fat abnormalities in HIV-infected patients.

American Journal of Infectious Diseases
Volume 2 No. 3, 2006, 184-186

DOI: https://doi.org/10.3844/ajidsp.2006.184.186

Submitted On: 12 July 2006 Published On: 30 September 2006

How to Cite: Grinspoon, S. (2006). Abnormal Glucose Regulation and Treatment Strategies for Insulin Resistance HIV-Infected Patients. American Journal of Infectious Diseases, 2(3), 184-186. https://doi.org/10.3844/ajidsp.2006.184.186

Open AccessCopyright: © 2006 Steven Grinspoon. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • HIV-infected patients
  • abnormalities
  • insulin resistance
  • glucose regulation