Non-Hodgkin Lymphoma Risk Grading Through the Pathological Data by Using the Optimized Convolutional Lymphnet Model

Abstract

Diagnosing Non-Hodgkin Lymphoma (NHL) is difficult and often requires specialised training and expertise as well as extensive morphological investigation and, in certain cases, costly immunohistological and genetic techniques. Computational approaches enabling morphological-based decision making are necessary for bridging the existing gaps. Histopathological images can be accurately classified using deep learning approaches, however data on NHL subtyping is limited. However, there is a lack of data about the categorization of lymph nodes affected by Non-Hodgkin Lymphoma. Here in this study, initially image preprocessing was done using the maximal Kalman filter which helps in removing the noise, data augmentation was done to improve the dataset, then the lymph nodal area was segmented using the sequential fuzzy YOLACT algorithm. Finally we trained and optimized an Convolutional Lymphnet model to classify and grade tumor level from tumor-free reference lymph nodes using the grey wolf optimized model by selecting the fitness parameters and optimize it for identifying the patient risk score. The overall experimentation was carried out under python framework. The findings demonstrate that the recommended strategy works better than the state-of-the-art techniques by having excellent detection and risk score prediction accuracy.